Rather, it may have various shapes such as, for example, rectangular, tubular, conical, hour-glass, hemi-toroidal, etc. In some variations of the invention an obturator is used within the device, where the obturator is slidably located within the lumen of the elongate body and piercing member. By controlling the length of the control segments, the shape of the deployed conduit may be controlled. A guide wire may be used to place the delivery device into the collateral channel In this example the implant would be placed over a blue deflated balloon catheter. Alternatively, the piercing member may be of a sufficient size or construction that the hole remains open upon removal of the piercing member.
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The best performance on water immersion was obtained from use of the E resin, about 0. As in the Koul study, twenty rats can undergo a bilateral injection of a non-echogenic polymer solution in DMSO and twenty rats can undergo a bilateral injection of an echogenic polymer composition see Koul V. Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate. In one aspect, double emulsion is used to prepare microbubbles containing perfluorocarbon gas. In embodiments, the length of occlusion produced in the vas deferens as a result of administering the occlusive substance can range from 0. Aspect is the composition of Aspect , wherein the life span of the composition is days, weeks, months, or years, and is preferably permanent. In one aspect, multiple tags are used as backups.
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According to embodiments, a vas-occlusive polymer can then be administered into the vas deferens of both sides by way of percutaneous injection or controlled intra-vasal infusion into the vas, optionally under the guidance of ultrasound imaging. The above procedure can then be repeated on the contralateral side. According to one embodiment, the injection volume and length of polymer plug that forms is determined such that the subject becomes severely oligospermic or azoospermic as determined by analysis of semen samples. Examples of such acids, anhydrides and derivatives thereof, include maleic acid, fumaric acid, itaconic acid, citronic acid, acrylic acid, glycidyl acrylate, C 2 to C 10 alkyls, cyano-acrylate, hydroxy C 2 to C 10 alkyl methacrylates, acrylic polyethers, acrylic anhydrides, methacrylic acid, crotonic acid, isocrotonic acid, mesaconic acid, angelic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, acrylonitrile, and methacrylonitrile. Results suggest that moisture added and soaking time are key factors that affect the seepage depth, water content, and resilient modulus.
US8764708B2 - MEMS device and method for delivery of therapeutic agents - Google Patents
Description: The microbubbles can range in size from about 0. The method of claim 1 , wherein the middle deflection layer comprises a bellows structure. Record the temperature at which the bond fails and the weight falls. A preferred group of tackifying resins include the Escorez brand tackifying resins produced by Exxon Chemical Company, Polymers Group.